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Clomipramine -- Description

Abstract: Clomipramin belongs to the category of tri-cyclic antidepressive medicines. It is used for the treatment of depression and Obsessive Compulsive Disorder (OCD).

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Clomipramine -- Description

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Written by:
  1. Petros Skapinakis, MD, MPH, PhD, lecturer of Psychiatry in the University of Ioannina Medical School, Greece.
  2. Eva Gerasi, postgraduate student in the Department of Psychiatry, University Hospital of Ioannina, Greece.
  3. Jacob Palme, professor, Stockholm University
First version: 22 Jul 2008.
Latest revision: 03 Mar 2013.

What is clomipramine (Anafranil)?


  • Clomipramine (Anafranil) is in a class of drugs called tricyclic antidepressants. Clomipramine affects chemicals in the brain that may become unbalanced and cause obsessive-compulsive disorder. Clomipramin has had a wide usage for the treatment of depression, but nowadays SSRI medicines are used instead, since they have the same positive effect but less unwanted side effects.
  • Clomipramine is used to relieve symptoms of obsessive-compulsive disorder such as recurrent thoughts or feelings and repetitive actions.
  • Clomipramine increases the pain killing effects of opioids (morphine, methadone, etc.)
  • Clomipramine may also be used for purposes other than those listed here.
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