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Citalopram (Celexa, Seropram, Cipramil) - Counteractions

Abstract: Cautions when combining citalopram with other drugs.

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Citalopram (Celexa, Seropram, Cipramil) - Counteractions

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Written by: Petros Skapinakis, MD, MPH, PhD, lecturer of Psychiatry in the University of Ioannina Medical School, Greece. Eva Gerasi, postgraduate student in the Department of Psychiatry, University Hospital of Ioannina, Greece.
First version: 22 Jul 2008.
Latest revision: 22 Jul 2008.

What other drugs will affect citalopram (Celexa, Seropram, Cipramil)?

Answer:

  • Citalopram should not be taken if the patient has taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), or tranylcypromine (Parnate) during the last 2 weeks. A dangerous drug interaction can occur when citalopram is combined with any of these medications.
  • Before taking citalopram, the patient should tell his/her doctor if he/she is taking any of the following medicines:
    • another antidepressant such as fluoxetine (Prozac), fluvoxamine (Luvox), sertraline (Zoloft), paroxetine (Paxil), trazodone (Desyrel), or nefazodone (Serzone);
    • a tricyclic antidepressant such as amitriptyline (Elavil), imipramine (Tofranil), doxepin (Sinequan), nortriptyline (Pamelor), and others;
    • a seizure medication including carbamazepine (Tegretol) or felbamate (Felbatol);
    • a stomach medicine such as cimetidine (Tagamet, Tagamet HB), ranitidine (Zantac, Zantac 75), or omeprazole (Prilosec);
    • an antibiotic such as erythromycin (Eryc-Tab, E-Mycin, E.E.S., Erythrocin, P.C.E., others) or clarithromycin (Biaxin);
    • an antifungal medication such as fluconazole (Diflucan), itraconazole (Sporanox), or ketoconazole (Nizoral);
    • a migraine medication such as almotriptan (Axert), eletriptan (Relpax), frovatriptan (Frova), naratriptan (Amerge), rizatriptan (Maxalt), sumatriptan (Imitrex), or zolmitriptan (Zomig);
    • the asthma medication zafirlukast (Accolate); or
    • lithium (Eskalith, Lithobid, Lithonate, Lithotabs).

    They may not be able to take citalopram, or they may require a dosage adjustment or special monitoring during treatment if they are taking any of the medicines listed above.
  • Drugs other than those listed here may also interact with citalopram. Patients should talk to their doctor and pharmacist before taking any prescription or over-the-counter medicines, including herbal products.
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