With medicines, such as serotonergic anti-depressants or SSRIs (Seroxat, Prozac, Cipramil, Zoloft, Duloxetine, Xeristar) the ejaculation can be delayed. This medication improves the transmittal of serotonin (a substance in the body) between two nerves. These medicines need to be taken 2 to 3 hours before the expected sexual activity. This can be experienced as a disadvantage, because it reduces the spontaneity around making love. Some people take such medicines every day, avoiding this disadvantage but increasing the risk of side effects.

A medicine in this class, which is marketed especially for the treatment of premature ejaculation, has the name Priligy.

Good results have also been obtained with sexological treatments. This treatment is aimed at giving the man control over the ejaculation. A part of this is to withdraw the penis while making love to stop stimulation and thus prevent premature ejaculation.

In some mild cases, use of a condom may help.