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Tricyclic Antidepressants - Effects and Contra-Indications

Written by: Petros Skapinakis, MD, MPH, PhD, lecturer of Psychiatry in the University of Ioannina Medical School, Greece. Eva Gerasi, postgraduate student in the Department of Psychiatry, University Hospital of Ioannina, Greece.
First version: 22 Jul 2008. Latest version: 29 Jul 2008.


When are tricyclic antidepressants used and why? When are they not?


When are TCAs used and why? When are they not?


This type of medication is used to help relieve the symptoms of major depression.

When these drugs are not used:

They work as well as selective serotonin re-uptake inhibitors and a psychological treatment called cognitive behaviour therapy.

There exist the following: amitriptyline, desipramine, doxepin, imipramine, nortriptyline, protriptyline, trimipramine.

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