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Selective Serotonin Re-Uptake Inhibitors - How They Work

Written by: Petros Skapinakis, MD, MPH, PhD, lecturer of Psychiatry in the University of Ioannina Medical School, Greece. Eva Gerasi, postgraduate student in the Department of Psychiatry, University Hospital of Ioannina, Greece.
First version: 22 Jul 2008. Latest version: 22 Mar 2016.


SSRIs stabilizes the neurotransmitter serotonin, and reduces dominating but troublesome thoughts.


How do SSRIs work?


Serotonin is a brain neurotransmitter, which is felt to be heavily involved in the cause of depression. As a result drugs which specifically affect this neurotransmitter have been developed. As such they have the advantage of fewer side effects than older drugs. SSRIs relieve depression in most people who take them. There is some evidence that they may be more effective than other medications at treating people with uncommon symptoms of depression, such as eating or sleeping too much or being overly sensitive to rejection.

Some medicines in this group: Fluoxetin, Fontex, Prozac, Citalopram, Cipramil, Paroxit, Seroxat, Sertralin, Zoloft, Fluvoxamin, Fevarin. They are somwehat similar to Anafranil.

About SSRIs:
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