Nefazodone is a mixed selective serotonin reuptake inhibitor and 5HT2 receptor antagonist. It is as effective in treating depression as SSRIs.

It has side effects similar to those of selective serotonin reuptake inhibitors (SSRIs). The most common side effects of nefazodone are:

• Dry mouth
• Blurred vision
• Constipation
• Low blood pressure when standing

Additional negative side effects of nefazodone are possible but rare. They include allergic reaction, nausea, ringing in the ears, headaches, insomnia, and possibly seizures. It is free of gastrointestinal side effects and the sexual dysfunction seen with SSRIs. It is more sedative so it helps sleep, but it causes some postural hypotension.

Nefazodone hydrochloride should not be taken if the patient has had a previous allergic reaction to this medication. It should also not be used if they are taking a MAOI.