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Medicines against Compulsive Gambling / Gambling Addiction

Abstract: Naltrexone was in one study found to be efficient treatment of compulsive gambling. Naltrexone was more effective than SSRI-s, but a combination of Naltrexone and SSRI-s may be even more effektive.

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Medicines against Compulsive Gambling / Gambling Addiction

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Written by: Martin Winkler
First version: 22 Jul 2008.
Latest revision: 22 Jul 2008.

Are there medicines against gambling addiction? Is Naltrexone useful for the treatment of compulsive gambling?


I found an article abstract in the biggest international database Medline concering this topic by JE Grant and SW KIM :

Ann Clin Psychiatry 2002 Sep;14(3):155-61 Effectiveness of pharmacotherapy for pathological gambling: a chart review.

Grant JE, Kim SW.

Department of Psychiatry, University of Minnesota School of Medicine, Minneapolis, Minnesota 55454-1495, USA.

Although pathological gambling is a relatively common disorder, there exists only limited information regarding the effectiveness of pharmacotherapy for this illness. This study examines which medications may be effective, dose and duration of medication trials needed to achieve response, and possible predictors of response. Using a chart review, 50 adult outpatients with DSM-IV pathological gambling treated in clinical practice were assessed regarding response to a variety of medications, including augmentation strategies, and response to concomitant psychotherapy. All subjects received pharmacotherapy for gambling symptoms. Thirty-nine (78%) achieved response to medication treatment. Mean duration of treatment needed for response was 104.9 +/- 85.0 days. Of those treated with an adequate trial of naltrexone as monotherapy, 90.9% were responders, whereas only 45.5% of those treated with an adequate trial of an SSRI achieved response. Patients with poorer social and occupational functioning due to urges and thoughts about gambling were less likely to respond to medication. These findings from a clinical setting suggest that a majority of pathological gamblers improve with medication treatment. Naltrexone, or augmentation of naltrexone with an SSRI, appears to be most effective in relieving gambling symptoms.

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