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Independent medical expert answers
on psychiatry and psychology

Can Medicines Cause Sexual Orgasm Problems?

Abstract: All medicines have side effects and some of them will have an influence on sexual orgasm problems.

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Can Medicines Cause Sexual Orgasm Problems?

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Written by: Wendy Moelker, psychologist in charge of Emergis, Goes, the Netherlands.
First version: 22 Jul 2008.
Latest revision: 18 Jan 2013.

Can medicines cause sexual orgasm problems?

Answer:

All medicines have side effects and some also on the sexual function or perception. It is sometimes hard to determine what the real cause is. Is it the disease for which the medication is used, the medication itself or the sick person who reacts in his/her own way to the disease? That the medication has a certain influence is most probable when:
  • The side effects begin immediately after the start of the therapy.
  • The sexual disorder didn't exist before the therapy.
  • The problem stops after suspending the use of the medicine and.
  • The problem returns after starting to use the medicine again.
  • Some medicines are known for having more of such side effects than others. In the group of anti-depressants, anti-psychotics and some antihypertensives the frequency is about 10 to15 percent.

Antihypertensives:

  • Chlorthalidone (Hygroton; Thalitone): reduced desire and erection disorder.
  • Hydrochlorthiazide (Accupro, Amiloferm, Atacand, CoAprovel, Cozaar, Dicholtride, Esidrex, Inhibace, Moduretic, Monopril, Normorix, Renitec, Sparkal, Synerpril, Triatec, Zestoretic): reduced desire and erection disorder.
  • Metoprolol (Logimax, Seloken): reduced desire and erection disorder.
  • Spiromolactone (Aldactone): reduced desire and erection disorder.
  • Atenolol (Selinol, Ternormin, Uniloc) and propanolol (Inderal): erection disorder
  • Labetalol (lots of different brand names): erection disorder, reduced lubrication of the vagina and reduced ejaculation.
  • Enalapril (Renitec) and lisiopril (Vivatec, Zestoretic, Zestril): erection disorder.
  • Verapamil (Isoptin, Tarka): erection disorder, reduced ejaculation and orgasm problems.
Anti-anxiety agents:
  • Diazepam and oxazepam etc. (More): reduced desire and reduced ejaculation.
Anti-depressants (More):
  • Amitriptyline (Saroten, Tryptizol,Elavil, Endep), clomipramine(Anafranil) and imipramine (Tofranil): reduced desire, erection disorder and orgasm problems.
  • Fluoxetine (Prozac, Fontex): reduced desire, erection disorder, reduced ejaculation and orgasm problems.
  • Paroxetine (Seroxat, Paxil): reduced ejaculation.
  • Sertraline (Zoloft): reduced ejaculation.
  • Other anti-deprssants: Celexa, Cipramil, Citalopram, Dopax, Escitalopram, Fevarin, Fluvoxamin, Lexapro, Luvox, Paroxat, Paroxetin, Paxil, Remeron, Seropram, Seroscand, Seroxat, Sertraline, Ssri, Zoloft, etc.: orgasm problems.
Anti-psychotics:
  • Lithium (Lithonit): reduced desire, erection disorder and reduced ejaculation
  • Pimozide (Orap): reduced desire, erection disorder and reduced ejaculation.
  • Thioridazine (Malloril, lots of other brand names)): erection disorder, reduced ejaculation and orgasm problems.
  • Haloperidol (Haldol) and droperidol (Dridol): reduced desire and erection disorder.
Cholesterol reducers:
  • Atorvastatin (Lipitor) and simvastatin (Zocord): erection disorders.
  • Gemfibrozil (Lopid): reduced desire and erection disorders.
  • Digoxin (Lanacrist, Lanoxin): reduced interest and erection disorders.
Drugs and pain killers:
  • Morphine: reduced desire, erection disorder and reduced ejaculation.
  • Codeine, Ibuprofen and other pain killers can cause erection and orgasm problems.
  • Methadone, Subutex and Subuxone: reduced desire, erection disorder, reduced ejaculation and orgasm problems.
  • Marihuana: reduced desire.
  • Etc.
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