But recent research showed some promissing effects for patients with self-injurious behavior (SIB) and dissociative symptoms of trauma (PTSD) or borderline personality disorder (BPD). This might be a medical option for patients with different kinds of self-harm behavior (including cutting, self-biting or self-hitting/slapping) and could also be a possible treatment approach for mentally retarded young patients with SIB.

Trials of patients with gambling addiction indicates that Naltrexone can be a help with gambling addicion, usually in combination with SSRI drugs and psychotherapy.

Researchers in Germany made a study of female patients with Borderline personality disorder with dissociative symptoms. The patients received 25 to 100 mg naltrexone four times a day for at least 2 weeks. Results of self-rated questionaire for dissociation (DAISS) showed a significant reduction of the symptoms, indluding flashbacks and self-harm. The authors presented the hypothesis that an increased activity of the opioid system contributes to dissociative symptoms of these patients.